AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis
نویسندگان
چکیده
منابع مشابه
Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis.
Neurodegeneration is the irremediable pathological event occurring during chronic inflammatory diseases of the CNS. Here we show that, in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, inflammation is capable in enhancing glutamate transmission in the striatum and in promoting synaptic degeneration and dendritic spine loss. These alterations occur early in...
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Helmar Waiczies, Stefano Lepore, Jason M Millward, Bettina Purfürst, Thoralf Niendorf, and Sonia Waiczies Ultrahigh Field Imaging in Neuroinflammation, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Deutschland, Germany, Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Center for...
متن کاملExperimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). MS is also named encephalomyelitis disseminata (ED). EAE has been also called experimental allergic encephalomyelitis, but the word `allergic` is more and more replaced by the word `autoimmune`. This has to do with the deeper understanding of the disease biology that has been gathered over the last ye...
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Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that Panx1-mediated ATP release contributes to expression of Experimental Autoimmune Encephalomyelitis (EAE), an animal model for multiple sclerosi...
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Molecular mimicry refers to structural homologies between a self-protein and a microbial protein. A major epitope of myelin basic protein (MBP), p87-99 (VHFFKNIVTPRTP), induces experimental autoimmune encephalomyelitis (EAE). VHFFK contains the major residues for binding of this self-molecule to T cell receptor (TCR) and to the major histocompatibility complex. Peptides from papilloma virus str...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2021
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.20201796